3-O-(2，3-二甲基丁?；?-13-O-十二烷酰基巨大戟二萜醇

3-O-(2,3-dimethylbutanoyl)-13-O-decanoylingenol   CAS: N.A     分子量：660.46       分子式：C39H64O8

純       度：      HPLC98%
物理性狀：     油狀液體
檢測方法：     高效液相（HPLC）質(zhì)譜（Mass) 核磁（NMR)
用      途：      僅供研究使用,不得用于醫(yī)學診斷。
包      裝：      20mg~1g 棕色玻璃瓶。
儲存條件：     貯存在避光密閉容器中，冷藏或者冷凍長期保存。
樣品溶液現(xiàn)配現(xiàn)用。如果特殊情況需要提前配制的話，最好分成獨立包裝冷凍保存（-20℃以下），臨用前再取出解凍，通常可以保存2周。

植物來源
  大戟科植物甘遂EuphorbiakansuiT.N.LiouexT.P.Wang的干燥塊根

藥理研究

• 3-O-(2,3-dimethylbutanoyl)-13-O-decanoylingenol (DBDI)purified from the Euphorbia kansui L., inhibits degranulation in rat basophilic leukemia 2H3 cells upon aggregation of the FcepsilonRI. In the present study, we demonstrated that the DBDI significantly inhibits release of beta-hexosaminidase, synthesis of eicosanoids, and mobilization of intracellular Ca(2+) in the bone marrow-derived mouse mast cells stimulated with IgE and antigen. Furthermore, we revealed that phosphorylation of Syk, phospholipase C-gamma(2), and extracellular signal-related kinase 1/2 is significantly suppressed in the DBDI-treated mast cells. These findings suggest that the DBDI may have a therapeutic potential for allergic diseases by inhibiting intracellular signaling pathways for activation and chemical mediator release in mast cells.

• 大戟屬植物作為大戟科植物最大的屬,由于該屬藥用植物具有良好的抗腫瘤、抗白血病、抗菌、抗炎、抗病毒、抗結(jié)核等藥理活性,

參考文獻

• [1].  3-O-(2,3-Dimethylbutanoyl)-13-O-decanoylingenol from Euphorbia kansui Suppresses IgE-Mediated Mast Cell Activation [J].Bid Phann Bull,2006,29(2):286 290.

• [2] 包勒朝魯 那生桑.大戟屬藥用植物的毒性及炮制減毒增效研究進展.世界科學技術(shù)[J]. 中醫(yī)藥現(xiàn)代化.2018年第20卷第4期 585-591